Antioxidant activity of Curcumin

In the past few years, multiple drugs have been produced from traditional raw materials and recent pandemic disease COVID-19 once again research on this matter is being conducted to determine potential therapeutic purposes of different Ayurvedic Indian medicines and herbs. One such medicinal herb is Curcuma longa. Curcumin is strong antioxidant, anti-inflammatory, antispasmodic, antiangiogenic, anti-carcinogenic, as shown by multiple in vitro and in vivo studies. The action of the growth factor receptors is inhibited by curcumin. The anti-inflammatory effect of curcumin is obtained on the cytokines, proteolytic enzymes, eicosanoids, and lipid mediators. The superoxide radicals, nitric oxide and hydrogen peroxide, are sifted by curcumin, while lipid peroxidation is inhibited. Such properties of the compound thus form the foundation for its various therapeutic and pharmacological effects could also hold antiviral properties including COVID-19. The aim of this research is to summarize the updated pharmacological activities of curcumin. © RJPT All right reserved.

Impact of COVID-19 on multiple body organ failure: A review

COVID-19 is a highly contagious disease caused by Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2) which is a novel single-stranded positive RNA infection which consist of cytokines that activate the pathogenic systems that cause high respiratory pain condition and adversely effect on multiple body organ in humans as per their immunity standards to fight against the virus. SARS-CoV-2 enters the host cell through Angiotensin-Converting Enzyme 2 (ACE 2). ACE 2 is a sub-part of the Renin-Aldosterone Angiotensin System (RAAS) which is intelligently communicated in the kidney, heart, lungs and fatal tissues of the body. The malfunctioning of RAAS in the body leads to hypertension, cardiovascular sicknesses, endocrine system and also affect negatively a brain body communication channel. Treatments on the RAAS structure, thiazolidinedione’s and smoking, toxaemia, kidney, lungs disorder due to the SARS-CoV-2 attack on the host cell and notice the behavioural changes of body organs on the arrival of cytokines that causes multi-organ damage. This paper involves the study of the effects of coronavirus disease on multiple body-organ damages.

Impact of covid-19 on multiple body organ failure: A review

COVID-19 is a highly contagious disease caused by Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2);which is a novel single-stranded positive RNA infection which consist of cytokines that activate the pathogenic systems that cause high respiratory pain condition, and adversely affect on multiple body organ in humans as per their immunity standards to fight against the virus. SARS-CoV-2 enters the host cell through Angiotensin-Converting Enzyme 2 (ACE 2). ACE 2 is a sub-part of the Renin-Aldosterone Angiotensin System (RAAS), intelligently communicated in the body's kidney, heart, lungs, and malignant tissues. The malfunctioning of RAAS in the body leads to hypertension, cardiovascular sicknesses, endocrine system and negatively affects a brain-body communication channel. Treatments on the RAAS structure, 'thiazolidinedione's and smoking, toxemia, kidney, lungs disorder due to the SARS-CoV-2 attack on the host cell and notice the behavioral changes of body organs the arrival of cytokines that causes multi-organ damage. This paper involves the study of the effects of coronavirus disease on multiple body-organ injuries. © 2021 The Authors.

Plant Cell and Callus Cultures as an Alternative Source of Bioactive Compounds with Therapeutic Potential against Coronavirus Disease (COVID-19)

Plant cell and callus cultures are important tools for the mass production of bioactive compounds (secondary metabolites) from plants cell or tissue under a controlled environment. From past few decades the bioactive compounds assumed to play a key role in the development of novel drugs against several viral diseases, causing serious threat and even death to thousands of human lives. The recent, pandemic coronavirus disease (COVID-19) outbreak upraised the importance of developing an effective therapeutic drug or vaccine as quick as possible to treat or prevent further spread. The research studies are in progress to find coronavirus therapeutics among existing antiviral drugs. Of these drugs, hydroxychloroquine and azithromycin have emerged as frontrunners and shown early promising results in treating COVID-19 in both in vitro and in vivo studies. However, these drugs have adverse side-effects and they became ineffectual due to eventual drug-resistance. Research is continuing by several means in search of potential therapeutics with minimal side-effects. The natural bioactive compounds from a plant sources generally have minimal toxicity can exert inhibitory capacity against coronavirus is of great interest. Up to now, various phytochemical compounds, namely arctiin, scutellarin, forsythoside, kaempferol, secoxyloganin, nicotianamine, saikosaponin, reported to have anti-SARS-CoV-2 activity. The mechanism of action appears to be inhibiting virus replication and blocking viral infection. Due to time taking cultivation, expensive extraction and isolation of bioactive constituents, it is essential to develop alternative techniques for the mass production of bioactive compounds in a less timeframe using in vitro methods of plant cell and callus culture methods. In the present work, we highlighted the importance of modern biotechnological approaches including cell or tissue or callus culture methods and plant-based antiviral compounds currently being tested to treat novel coronavirus. © Published under licence by IOP Publishing Ltd.